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| Cat. Number | T7035 |
| Chemical Name | T7035 Triptolide 38748-32-2 |
| CAS Number | 38748-32-2 |
| Mol. Formula | C20H24O6 |
| Mol. Weight | 360.4 |
| Qty 1 |
1mg |
| Qty 2 | 5mg |
| Appearance | White Powder |
| Application Notes | ≥98% |
| Synonym | PG490 |
| Melting Pt. | 227-228°C |
| Solubility | Soluble in DMSO. |
| Storage condition | 4°C |
| References | Triptolide is a diterpenoid epoxide originally found in Tripterygium that exhibits anticancer chemotherapeutic, anti-angiogenic, antinociceptive, anti-inflammatory, anti-fibrotic, and immunosuppressive activities. Triptolide induces apoptosis and decreases β-catenin expression in breast cancer cells. In cellular and animal models of pancreatic cancer, triptolide inhibits cell proliferation and xenograft growth, downregulates expression of COX-2 and VEGF, and suppresses cell migration and tube formation. In animal models, chronic administration of triptolide decreases activation of glial cells and phosphorylation of MAPKs, suppressing neuropathic pain. Additionally, triptolide decreases expression of IL-17 and STAT3 and suppresses neutrophil migration, displaying hepatoprotective benefit in animal models of liver ischemia/reperfusion injury. Triptolide also prevents the development of cardiac fibrosis and improves cardiac function in animal models of chronic heart failure. ReferencesLiu M, Chen J, Huang Y, et al. Triptolide alleviates isoprenaline-induced cardiac remodeling in rats via TGF-β1/Smad3 and p38 MAPK signaling pathway. Pharmazie. 2015 Apr;70(4):244-50.PMID: 26012254. Shao H, Ma J, Guo T, et al. Triptolide induces apoptosis of breast cancer cells via a mechanism associated with the Wnt/β-catenin signaling pathway. Exp Ther Med. 2014 Aug;8(2):505-508. PMID: 25009609. Ma JX, Sun YL, Wang YQ, et al. Triptolide induces apoptosis and inhibits the growth and angiogenesis of human pancreatic cancer cells by downregulating COX-2 and VEGF. Oncol Res. 2013;20(8):359-68. PMID: 23924856. Wang W, Mei XP, Chen L, et al. Triptolide prevents and attenuates neuropathic pain via inhibiting central immune response. Pain Physician. 2012 Nov-Dec;15(6):E995-1006. PMID: 23159984. Wu C, Xia Y, Wang P, et al. Triptolide protects mice from ischemia/reperfusion injury by inhibition of IL-17 production. Int Immunopharmacol. 2011 Oct;11(10):1564-72. PMID: 21621648. 上海惠诚生物科技有限公司自2010年成立以来，一直致力于为客户提供试剂，仪器设备和耗材一站式服务。目前在苏州和南通的研发生产基地，专注于体外诊断蛋白，靶标蛋白，工业用酶和细胞因子的生产和定制，按照GMP标准，为工业客户提供大包装蛋白原料。
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