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Cat. Number
Tramiprosate
Chemical Name
Tramiprosate
CAS Number
[3687-18-1]
Mol. Formula
C3H9NO3S
Mol. Weight
139.17
Qty 1
50mg
Synonym
3-Amino-1-propanesulfonic acid
Solubility
Soluble to 100 mM in water
Storage condition
Store at +4°C
References
Sulfated glycosaminoglycan (sGAG) mimetic that targets soluble amyloid β (Aβ) and maintains Aβ in a non-fibrillar form. Decreases Aβ42-induced neuronal death and inhibits amyloid deposition in vitro. Decreases brain amyloid plaque load by 30%, increases tau polymerization and is brain penetrant. Also a GABA analog that protects against the convulsant and cytotoxic activity of kainic acid in vivo.
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