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| Cat. Number | U0126 |
| Chemical Name | U0126 |
| CAS Number | [109511-58-2] |
| Mol. Formula | C18H16N6S2 |
| Mol. Weight | 380.48 |
| Qty 1 |
5mg |
| Qty 2 | 25mg |
| Synonym | 1,4-Diamino-2,3-dicyano-1,4-bis[2-a minophenylthio]butadiene |
| Solubility | Soluble to 100 mM in DMSO |
| Storage condition | Desiccate at +4°C |
| References | Potent and selective non-competitive inhibitor of MAP kinase kinase. Inhibits MEK-1 and MEK-2 (IC50 values of 0.07 and 0.06 μM respectively) with little or no effect on the activities of PKC, Abl, Raf, MEKK, ERK, JNK, MKK-3, MKK-4/SEK, MKK-6, Cdk2 or Cdk4. Centrally active following systemic administration in vivo. Also available as part of the MAPK Cascade Inhibitor Tocriset™ and MAPK Inhibitor Tocriset™. Negative control U0124 (Cat. No. 1868) also available. |
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