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| Cat. Number | XMD 8-92 |
| Chemical Name | XMD 8-92 |
| CAS Number | [1234480-50-2] |
| Mol. Formula | C26H30N6O3 |
| Mol. Weight | 474.55 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | 2-[[2-Ethoxy-4-(4-hydroxy-1-piperid inyl)phenyl]amino]-5,11-dihydro-5,11-dimethyl-6H-p yrimido[4,5-b][1,4]benzodiazepin-6-one |
| Solubility | Soluble to 40 mM in DMSO |
| Storage condition | Store at RT |
| References | Highly selective ERK5/BMK1 inhibitor (KD values are 80, 190, 600 and 890 nM for BMK1, DCAMKL2, PLK4 and TNK1 respectively). Displays selectivity over 402 diverse kinases. Blocks growth factor-induced activation of cellular BMK1 and reduces BMK1 activity in in vitro kinase assays. Also reduces BMK1-dependent transactivating activity of MEF2C. Inhibits proliferation in a variety of cancer cell lines; blocks tumor cell proliferation and tumor-associated angiogenesis. Purity: >98 % |
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