服务热线
021-60498804
| Cat. Number | X0384 |
| Chemical Name | X0384 XAV-939 284028-89-3 |
| CAS Number | 284028-89-3 |
| Mol. Formula | C14H11F3N2OS |
| Mol. Weight | 312.31 |
| Qty 1 |
5mg |
| Qty 2 | 25mg |
| Application Notes | ≥98% |
| Synonym | 3,5,7,8-Tetrahydro-2-[4-(trifluorom ethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one |
| Solubility | DMSO (25mg/ml) |
| Storage condition | -20°C |
| References | XAV-939 inhibits tankyrases and wnt pathway signaling. XAV exhibits anti-fibrotic activity and shows potential anticancer chemotherapeutic benefit when co-administered with other compounds. XAV-939 decreases nuclear accumulation of β-catenin and decreases c-myc levels, decreasing bleomycin-induced dermal thickening. In both in vitro and in vivo models of cancer, this compound reverses resistance to PI3K and Akt inhibitors. ReferencesBilir B, Kucuk O, Moreno CS. Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells. J Transl Med. 2013 Nov 4;11(1):280. [Epub ahead of print]. PMID: 24188694 Distler A, Deloch L, Huang J, et al. Inactivation of tankyrases reduces experimental fibrosis by inhibiting canonical Wnt signalling. Ann Rheum Dis. 2013 Sep 1;72(9):1575-80. PMID: 23148305. Tenbaum SP, Ordóñez-Morán P, Puig I, et al. β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer. Nat Med. 2012 Jun;18(6):892-901. PMID: 22610277. 上海惠诚生物科技有限公司自2010年成立以来，一直致力于为客户提供试剂，仪器设备和耗材一站式服务。目前在苏州和南通的研发生产基地，专注于体外诊断蛋白，靶标蛋白，工业用酶和细胞因子的生产和定制，按照GMP标准，为工业客户提供大包装蛋白原料。
更多产品请联系惠诚生物！ 蛋白原料网站：www.acediag.com 全国统一服务热线：021- 60496554 24小时手机服务: 13917250134（同微信）QQ：1715451510 Email：info@e-biochem.com |
下一个：XCC上一个：Xanthurenic acid |
|
Copyright © 2022 上海惠诚生物科技有限公司
沪ICP备2021037845号-6
