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| Cat. Number | YM 58483 |
| Chemical Name | YM 58483 |
| CAS Number | [223499-30-7] |
| Mol. Formula | C15H9F6N5OS |
| Mol. Weight | 421.32 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | N-[4-[3,5-Bis(trifluoromethyl)-1H-p yrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-c arboxamide |
| Solubility | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| Storage condition | Store at +4°C |
| References | Blocker of store-operated Ca2+ entry (SOCE), which mediates the activation of non-excitable cells (e.g. lymphocytes). Inhibits calcium release-activated calcium (CRAC) channels; suppresses thapsigargin-induced sustained Ca2+ influx (IC50 = 100 nM). Displays immuno-modulatory and anti-inflammatory effects; suppresses cytokine production and proliferation of T-cells in vitro. Purity: >99 % |
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