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Cat. Number
ZM 323881 hydrochloride
Chemical Name
ZM 323881 hydrochloride
CAS Number
[324077-30-7]
Mol. Formula
C22H18FN3O2.HCl
Mol. Weight
411.86
Qty 1
1mg
Qty 2
10mg
Synonym
5-((7-Benzyloxyquinazolin-4-yl)amin o)-4-fluoro-2-methylphenol hydrochloride
Solubility
Soluble to 50 mM in DMSO
Storage condition
Desiccate at +4°C
References
Potent and selective inhibitor of human vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) activity. Selectively inhibits VEGFR-2 (IC50 = 2 nM) over VEGFR-1 and a range of other receptor tyrosine kinases such as PDGFRβ, FGFR1, EGFR and erbB2 (IC50 > 50 μM). Inhibits VEGF-A-induced endothelial cell proliferation in vitro (IC50 = 8 nM).
Purity: >99 %
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