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| Cat. Number | HH0169 |
| Chemical Name | 三尖杉酯碱,Harringtonine |
| CAS Number | [26833-85-2] |
| Mol. Formula | C28H37NO9 |
| Mol. Weight | 531.59 |
| Qty 1 |
5mg |
| Qty 2 | 10mg |
| Application Notes | ≥97% |
| Synonym | Cephalotaxine, 4-methyl (2R)-2-hydroxy-2-(3-hydroxy-3- methylbutyl)butanedioate (ester) (9CI);Harringtonine |
| Melting Pt. | 73-75°C |
| Storage condition | -20°C |
| References |
Harringtonine is a cephalotaxine alkaloid originally isolated from Cephalotaxus hainanensis Li; it exhibits antiviral and anticancer activities. Harringtonine immobilizes initiated ribosomes, inhibiting protein translation by binding the A site of the 60 S ribosomal subunit and preventing aminoacyl-tRNA binding. Harringtonine inhibits chikungunya virus infection, suppressing replication, RNA production, and viral protein expression. Alone, harringtonine downregulates production of Mcl-1, increases cleavage of PARP, and inhibits cell growth in acute promyelocytic leukemia (APL) cells. Additionally, this compound improves the efficacy of co-administered chemotherapeutic compounds, further inhibiting proliferation and inducing apoptosis in leukemia cells. |
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