服务热线
021-60498804
| Cat. Number | B6998 |
| Chemical Name | B6998 BRYOSTATIN 1 83314-01-6 |
| CAS Number | 83314-01-6 |
| Mol. Formula | C47H68O17 |
| Mol. Weight | 905.03 |
| Qty 1 |
10µg |
| Qty 2 | 25µg |
| Appearance | Colorless Film or White Solid |
| Application Notes | ≥98% |
| Melting Pt. | 230-235°C |
| Solubility | Soluble in DMSO or ethanol. |
| Storage condition | -20°C |
| References | Bryostatin 1 is a macrolide lactone found in Bugula that exhibits neuroprotective, cognition enhancing, immunomodulatory, and anticancer chemotherapeutic activities. Bryostatin 1 activates PKC when administered acutely or in low doses and inhibits PKC when administered chronically or in high doses. Bryostatin 1 is currently in clinical trials as a co-administered chemotherapeutic in the treatment of various types of cancer. In animal models, this compound increases memory acquisition and storage. Additionally, bryostatin 1 activates PKD and decreases expression of β-catenin in vitro. In cellular models of Alzheimer’s disease, bryostatin 1 activates APP processing by α-secretase, decreasing levels of amyloid-β (Aβ). Bryostatin 1 improves MHC class II antigen presentation by CD4+ T cells in cellular models of Burkitt’s lymphoma and also activates toll-like receptor 4 (TLR4), inducing release of Th2 cytokines. ReferencesIrie K, Yanagita RC. Synthesis and biological activities of simplified analogs of the natural PKC ligands, bryostatin-1 and aplysiatoxin. Chem Rec. 2014 Apr;14(2):251-67. PMID: 24677503. Yi P, Schrott L, Castor TP, et al. Bryostatin-1 vs. TPPB: dose-dependent APP processing and PKC-α, -δ, and -ε isoform activation in SH-SY5Y neuronal cells. J Mol Neurosci. 2012 Sep;48(1):234-44. PMID: 22700373. Hossain A, God JM, Radwan FF, et al. HLA class II defects in Burkitt lymphoma: bryostatin-1-induced 17 kDa protein restores CD4+ T-cell recognition. Clin Dev Immunol. 2011;2011:780839. PMID: 22162713. Ariza ME, Ramakrishnan R, Singh NP, et al. Bryostatin-1, a naturally occurring antineoplastic agent, acts as a Toll-like receptor 4 (TLR-4) ligand and induces unique cytokines and chemokines in dendritic cells. J Biol Chem. 2011 Jan 7;286(1):24-34. PMID: 21036898. Jaggi M, Chauhan SC, Du C, et al. Bryostatin 1 modulates beta-catenin subcellular localization and transcription activity through protein kinase D1 activation. Mol Cancer Ther. 2008 Sep;7(9):2703-12. Erratum in: Mol Cancer Ther. 2009 May;8(5):1398. PMID: 18765827. Kuzirian AM, Epstein HT, Gagliardi CJ, et al. Bryostatin enhancement of memory in Hermissenda. Biol Bull. 2006 Jun;210(3):201-14. PMID: 16801495. 上海惠诚生物科技有限公司自2010年成立以来，一直致力于为客户提供试剂，仪器设备和耗材一站式服务。目前在苏州和南通的研发生产基地，专注于体外诊断蛋白，靶标蛋白，工业用酶和细胞因子的生产和定制，按照GMP标准，为工业客户提供大包装蛋白原料。
更多产品请联系惠诚生物！ 蛋白原料网站：www.acediag.com 全国统一服务热线：021- 60496554 24小时手机服务: 13917250134（同微信）QQ：1715451510 Email：info@e-biochem.com |
下一个：Buccalin上一个：Bilobalide |
|
Copyright © 2022 上海惠诚生物科技有限公司
沪ICP备2021037845号-6
