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| Cat. Number | A4577 |
| Chemical Name | A4577 Alsterpaullone 237430-03-4 |
| CAS Number | 237430-03-4 |
| Mol. Formula | C16H11N3O3 |
| Mol. Weight | 293.28 |
| Qty 1 |
1mg |
| Qty 2 | 5mg |
| Appearance | Yellow to Brown Powder |
| Application Notes | ≥98% |
| Synonym | 9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5)-one |
| Solubility | Soluble in DMSO |
| Storage condition | +4°C |
| Stability | Protect from light. |
| References | Alsterpaullone exhibits anticancer, anti-angiogenic, antiviral, and neuroprotective activities. Alsterpaullone inhibits cyclin-dependent kinases (CDKs), inducing G2/M phase cell cycle arrest and apoptosis in leukemia cells. Additionally, alsterpaullone inhibits glycogen synthase kinase 3 (GSK-3), inducing Wnt signaling; in ticks, this results in anti-fertility potential, decreasing egg hatching activity. Alsterpaullone also inhibits HIV-1 replication and proliferation. In ex vivo models of Alzheimer’s disease, this compound protects against neuronal death and decreases phosphorylation of tau protein. ReferencesCui C, Wang Y, Wang Y, et al. Alsterpaullone, a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells through Apoptosis-Inducing Effect. J Anal Methods Chem. 2013;2013:602091. PMID: 23577282. Windsor PJ, Leys SP. Wnt signaling and induction in the sponge aquiferous system: evidence for an ancient origin of the organizer. Evol Dev. 2010 Sep-Oct;12(5):484-93. PMID: 20883217. Zahler S, Liebl J, Fürst R, et al. Anti-angiogenic potential of small molecular inhibitors of cyclin dependent kinases in vitro. Angiogenesis. 2010 Sep;13(3):239-49. PMID: 20706783. Fabres A, De Andrade CP, Guizzo M, et al. Effect of GSK-3 activity, enzymatic inhibition and gene silencing by RNAi on tick oviposition and egg hatching. Parasitology. 2010 Sep;137(10):1537-46. PMID: 20500916. Guendel I, Agbottah ET, Kehn-Hall K, et al. Inhibition of human immunodeficiency virus type-1 by cdk inhibitors. AIDS Res Ther. 2010 Mar 24;7(1):7. PMID: 20334651. Selenica ML, Jensen HS, Larsen AK, et al. Efficacy of small-molecule glycogen synthase kinase-3 inhibitors in the postnatal rat model of tau hyperphosphorylation. Br J Pharmacol. 2007 Nov;152(6):959-79. PMID: 17906685. 上海惠诚生物科技有限公司自2010年成立以来，一直致力于为客户提供试剂，仪器设备和耗材一站式服务。目前在苏州和南通的研发生产基地，专注于体外诊断蛋白，靶标蛋白，工业用酶和细胞因子的生产和定制，按照GMP标准，为工业客户提供大包装蛋白原料。
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