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Cat. Number
TKA0025
Chemical Name
17-AAG
CAS Number
[75747-14-7]
Mol. Formula
C31H43N3O8
Mol. Weight
585.69
Qty 1
1mg
Qty 2
5mg
Synonym
17-(Allylamino)-17-desmethoxy-geldanamycin; allylaminogeldanamycin
Melting Pt.
200-205°C
Solubility
Soluble in DMSO or methanol
Storage condition
+4℃
Stability
Protect from light
References

An anologue of geldanamycin. It is a Hsp90 antagonist that induces apoptosis in human leukemia cells. It has been shown to enhance paclitaxel-mediated cytotoxicity and down-regulate vascular endothelial factor expression

Rahmani M, Yu C, Dai Y et al. Cancer Research. 63:8420-7 (2003).
Nguyen DM, Lorang D, Chen GA et al. Annals of Thoracic Surgery. 72:371-8 (2001).

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