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| Cat. Number | J8800 |
| Chemical Name | J8800 JW55 664993-53-7 |
| CAS Number | 664993-53-7 |
| Category | Xanthophylls |
| Mol. Formula | C25H26N2O5 |
| Mol. Weight | 434.49 |
| Qty 1 |
1mg |
| Qty 2 | 5mg |
| Appearance | |
| Application Notes | ≥98% |
| Synonym | Tankyrase 1/2 Inhibitor IV |
| Solubility | 10 mM in DMSO |
| Storage condition | -20C |
| References | JW55 is an inhibitor of tankyrases (TNKS1/2) that stabilizes the β-catenin degradation complex, suppressing Wnt signaling. JW55 displays anti-obesity and potential anticancer activities. In animal models of high-fat diet and diabetes, JW55 decreases body weight and intestinal epithelial stem cell proliferation. ReferencesMao J, Hu X, Xiao Y, et al. Overnutrition stimulates intestinal epithelium proliferation through β-catenin signaling in obese mice. Diabetes. 2013 Nov;62(11):3736-46. PMID: 23884889. Waaler J, Machon O, Tumova L, et al. A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice. Cancer Res. 2012 Jun 1;72(11):2822-32. PMID: 22440753. 上海惠诚生物科技有限公司自2010年成立以来，一直致力于为客户提供试剂，仪器设备和耗材一站式服务。目前在苏州和南通的研发生产基地，专注于体外诊断蛋白，靶标蛋白，工业用酶和细胞因子的生产和定制，按照GMP标准，为工业客户提供大包装蛋白原料。
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