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Cat. Number
733984758748150
Chemical Name
PD 173074
CAS Number
219580-11-7
Category
Aromatics, Heterocycles, Nucleotides, Bases & Related Reagents, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
Mol. Formula
C28H41N7O3
Mol. Weight
523.67
Qty 1
10mg
Qty 2
100mg
Appearance
Yellow Solid
Application Notes
A selective FGFR1 and FGFR3 inhibitor. The compound induced a dose-dependent reduce in cell viability and an increase in apoptosis, accompanied by a decrease in extracellular signal-related kinase phosphorylation.
Synonym
N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea
Melting Pt.
82-85°C
Solubility
Chloroform
Storage condition
Refrigerator
References

 

Mohammadi, M., et al.: Science, 276, 955 (1997),
Yagasaki, F., et al.: Cancer Res., 61, 8371 (2001),
Keats, J., et al.: Blood, 101, 1520 (2003),
Buchler, et al.: 9, 119 (2007),

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