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Cat. Number
733984896299543
Chemical Name
PD 0325901
CAS Number
391210-10-9
Category
Aromatics, Chiral Reagents, Pharmaceuticals, Intermediates & Fine Chemicals,
Mol. Formula
C16H14F3IN2O4
Mol. Weight
482.19
Qty 1
10mg
Qty 2
100mg
Appearance
White to Off-White Solid
Application Notes
The mitogenic extracellular kinase 1/2 (MEK1/2) inhibitor; has potent activity in a no. of cancer cell types in vitro.
Synonym
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide; PD 325901;
Melting Pt.
112-114°C
Solubility
DMSO, Methanol
Storage condition
-20°C Freezer, Under Inert Atmosphere
References

 

Davies, H., et al.: Nature, 417, 949 (2002),
Wellbrock, C., et al.: Cancer Res., 64, 2338 (2004),
Solit, D., et al.: Cancer Res., 67, 11463 (2007),
Adjei, A., et al.: J. Clin. Oncol., 26, 2139 (2008),

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