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Cat. Number
733984432894915
Chemical Name
Pamapimod-d4
Category
Amines, Aromatics, Heterocycles, Isotope Labelled Compounds, Pharmaceuticals, Intermediates & Fine Chemicals
Mol. Formula
C19H16D4F2N4O4
Mol. Weight
410.41
Qty 1
10mg
Application Notes
Labelled Pamapimod. A selective inhibitor of the α-isoform of p38 MAP kinase. It is used in in treatment of patient with rheumatoid arthritis. Pamapimod was tolerable but not effective as Methotrexate.
Synonym
6-(2,4-Difluorophenoxy)-2-[[3-hydroxy-1-(2-hydroxyethyl)propyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one-d4; R 1503-d4; Ro 4402257-d4;
References
Guan, Z., et al.: J. Biol. Chem., 273, 12901 (1998), Lee, J., et al.: Pharmacol. Ther., 82, 389 (1999), Korb, A., et al.: Arthritis Rheum., 54, 2745 (2006),
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