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/ Products Classification 点击展开+| Cat. Number | 733980324882596 |
| Chemical Name | Lometrexol |
| CAS Number | 106400-81-1 |
| Category | Aromatics, Chiral Reagents, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, |
| Mol. Formula | C21H25N5O6
|
| Mol. Weight | 443.45 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Application Notes | It is an antifolate which inhibits glycinamide ribonucleotide formyltransferase (GARFT), an enzyme essential for de novo purine synthesis. Lometrexol has activity against tumors which are refractory to other drugs, notably Methotrexate. |
| Synonym | N-[4-[2-[(6R)-2-Amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl]ethyl]benzoyl]- L-glutamic Acid ; LY 264618; |
| References | Gibbs, D., et al.: Cancer Res., 65, 11721 (2005), Gangjee, A., et al.: J. Med. Chem., 48, 5329 (2005), Hilgenbrink, A., et al.: J. Pharm. Sci., 94, 2135 (2005), |
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