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Cat. Number
733978412339871
Chemical Name
Hydroxy Bosentan
CAS Number
253688-60-7
Category
Aromatics, Heterocycles, Metabolites & Impurities, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
Mol. Formula
C27H29N5O7S
Mol. Weight
567.61
Qty 1
1mg
Qty 2
10mg
Appearance
White Solid
Application Notes
The active metabolite of Bosentan, a mixed endothelin receptor antagonist which is used as a vasodilator.
Synonym
4-(2-Hydroxy-1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-benzenesulfonamide; Ro 48-8634; Ro 48-5033
Melting Pt.
128-132°C
Solubility
Methanol
Storage condition
-20°C Freezer, Under Inert Atmosphere
References

Clozel, M., et al.: J. Pharmacol. Exp. Ther., 270, 228 (1994),
Gutsch, G., et al.: Cardiovasc. Drugs Ther., 10, 717 (1996),
Weber, C., et al.: Clin Pharmacol. Ther., 60, 124 (1996),
Krum, H., et al.: N. Engl. J. Med., 338, 784 (1998)

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