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/ Products Classification 点击展开+| Cat. Number | 733966416457670 |
| Chemical Name | ABT 888 |
| CAS Number | 912444-00-9 |
| Category | Amines, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals |
| Mol. Formula | C13H16N4O |
| Mol. Weight | 244.29 |
| Qty 1 |
10mg |
| Application Notes | ABT-888 is a potent, orally bioavailable PARP-1/-2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition was evaluated in vivo. |
| Synonym | 2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide; A 861695; |
| References | Virag, L., et al.: Pharmacol. Rev., 54, 375 (2002), Tentori, L., et al.: Clin. Cancer Res., 9, 5370 (2003), Kim, M., et al.: Cell, 119, 803 (2004), Tentori, L., et al.: Pharmacol. Res., 52, 25 (2005), |
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