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Cat. Number
733966487339737
Chemical Name
ABT 263-d8
Category
Chiral Reagents, Inhibitors, Isotope Labelled Compounds, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
Mol. Formula
C47H47D8ClF3N5O6S3
Mol. Weight
982.66
Qty 1
1mg
Qty 2
10mg
Appearance
Pale Yellow Solid
Application Notes
A novel inhibitor of antiapoptotic BCL-2 proteins; a new promising anticancer drug candidate.
Synonym
4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide-d8;
Melting Pt.
102-107°C
Solubility
Chloroform, DMSO
Storage condition
-20?C Freezer, Under Inert Atmosphere
References
Adams, J., et al.: Science, 281, 1322 (1998), Degterev, A., et al.: Nat. Cell. Biol., 3, 173 (2001), Kitada, S., et al.: J. Med. Chem., 46, 4259 (2003), Danial, N., et al.: Clin. Cancer Res., 13, 7254 (2007),
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