当前您的位置:首页>>产品动态>>技术资料>>维生素E:生育酚及三烯生育酚

 

Vitamin E: Tocopherols & Tocotrienols
维生素E系列产品
生育酚

 

Contents:
d-α-tocopherol, 98.5+% [CAS 59-02-9] 1 vial x 250 mg
d-β-tocopherol, 98.5+% [CAS 148-03-8] 1 vial x 250 mg
d-γ-tocopherol, 98.5+% [CAS 54-28-4] 1 vial x 250 mg
d-δ-tocopherol, 98.5+% [CAS 119-13-1] 1 vial x 250 mg
2,2,5,7,8-Pentamethyl-6-hydroxychroman (PMC), 99.0+% [CAS 950-99-2] 1 vial x 250 mg
Note: PMC is used as the internal standard for HPLC analysis of tocopherol, but not for GC analysis.
Storage condition:
Each vial is aluminum-packed with an oxygen adsorbent. One opening the vials, store the reagent under inert gas in a refrigerator in the dark. Under such conditions, the reagents are stable for 6 months.
Instruction for use (Preparation of each solution)
Weigh 50 ~ 100 mg of each reagent by chemical balance, to the nearest 0.1mg.
Add ethanol or hexane to dissolve the reagent to the final concentration of 1 mg vitamin homologue/mL as the stock solution. The stock solution in tightly capped vials are stable at 5 degrees C for a month.
The standard solutions for each homologue can be prepared by dilution the stock solution just before use.


1072                     rac-α-Tocopherol 50 mg  95+% TLC/98+% GC
1071                     rac-β-Tocopherol 50 mg  95+% TLC/98+% GC
1073                     rac-γ-Tocopherol  50 mg  95+% TLC/98+% GC
1790                     δ-Tocopherol        50 mg   95+% TLC/98+% GC
1074           rac-5,7-Dimethyltocol    50 mg  95+% TLC/98+% GC
1797                      Tocol                      50 mg  95+% TLC/98+% GC
α β γ δ -  三烯生育酚 标准品
Research use only. Do not administer it to human.
2109          α-Tocotrienol    25 mg  98+% TLC/98+% GC
2110          β-Tocotrienol    25 mg  98+% TLC/98+% GC
2111          γ- Tocotrienol    25 mg  98+% TLC/98+% GC
2112          δ-Tocotrienol    25 mg  98+% TLC/98+% GC

References:
1. Ahn, K., et al. (2007) J Biol Chem. 282:809-820
2. Kannappan, R., et al. (2010) J Biol Chem. 285:33520
3. Tan, B., (2005) The Journal of the American Neutricutical Association 8(1):35
4. Kannappan, R., et al. (2012) Genes Nutr. 7:43-52
5. Mangialasche, F., et al. (2012) Neurobiol. Aging 33(10):2282-2290
6. Patel, V., et al. (2011) Indian J Exp Biol. 49(10):732-738
7. Vasanthi, HR., et al. (2011) Curr Pharm Des. 17(21):2170-2175

     Vitamin E consists of four tocopherols and four tocotrienols that demonstrate important and far reaching biological activities.  These essential lipids contain a common chromanol ring and either a saturated (tocopherol) or unsaturated (tocotrienol) side chain.  The eight common vitamin E isoforms (α-, β-, γ-, and δ-tocopherols and α-, β-, γ-, and δ-tocotrienols) are differentiated based on the number and position of methyl groups on the chromanol ring and the presence of a saturated or unsaturated side chain (figure 1 (pg. 2)).  The vitamin E vitamers are commonly found in vegetables, fruits, seeds, nuts, grains and oils, where they exist in various ratios with each other.  The unsaturated side chain in tocotrienols gives them physical properties different from tocopherols, such as an increased ability to cross the cell membrane bilayer (1).  Vitamin E has become well known for its role as an antioxidant, in lowering cholesterol and other lipids, as a neuroprotective and anti-cancer agent, and in cardiovascular disease protection.  Most vitamin E supplements contain (and many studies use) only α-tocopherol; however, several of the above biological effects are mostly or exclusively found in the other vitamers, making it critical for them to be included in future research.  Indeed, the tocotrienols in general may have greater physiological functions than tocopherols (2) and may even be inhibited by an unbalanced excess of α-tocopherol supplements (3).
    Scientists at the MD Anderson Cancer Center wrote an excellent article entitled “Tocotrienols fight cancer by targeting multiple cell signaling pathways” (4).  Here it is suggested that since tumor cells result from dysregulation of multiple genes a drug is needed that will also target multiple genes.  Tocotrienols affect numerous pathways linked with tumorigenesis and thus have potential in both the prevention and treatment of cancer as an active and mild anti-cancer drug.
     A recent report from the Karolinska Institute in Sweden described the neuroprotective activity of tocopherols and tocotrienols (5).  It is indicated that low plasma tocopherol and tocotrienol levels are associated with an increased incidence of mild cognitive impairment and Alzheimer’s disease.  Another report indicates that α-tocotrienol is the most potent neuroprotective form of vitamin E, inhibiting 12-LOX, c-Src, and PLA2, up-regulating MRP1, and inducing arteriogenesis through induction of TIMP1 and decreased activation of MMP2 (6).

     Another beneficial function of tocopherols and tocotrienols is their role in preventing cardiovascular disease.  The tocotrienols particularly have gained eminence recently due to an increased understanding of their antioxidant effects.  Cardioprotective effects of tocotrienols include antagonizing the oxidation of low density lipoproteins, anti-atherosclerotic properties, inhibiting platelet aggregation and monocytes adhesion, and preventing smooth muscle proliferation (7).
    Since its discovery, vitamin E has been shown to be a versatile and potent component of biological systems.  α-Tocopherol has received much praise over the years due to its remarkable functions; now the less prevalent tocopherols and tocotrienols are starting to gain recognition as indispensable components of the vitamin E family.  As Kannappan et al. point out more than 25,000 studies have been conducted on tocopherol while very few studies have considered the role of tocotrienols (4).  
But this is sure to change as more scientists become aware that “The multitargeted role of tocotrienols in most degenerative diseases proves it to be an ideal candidate as a nutraceutical/pharmaceutical agent for useful exploitation” (7).  Matreya is pleased to introduce the full line of highly purified Tocopherols and Tocotrienols along with Tocols as internal standard markers.  We have the capability to produce these compounds in multigram sizes to accommodate your research.
16893 Vitamin E 
Synonyms:(R)-Tocopherol; (+)-α-Tocopherol;
D3413 Vitamin E 5,7,8-d9  98.3%D
Synonyms:Tocopherol-d9; α-Tocopherol-5,7,8-d9 (5-Cd3,7-Cd3,8-Cd3);
D32276 Vitamin E (5,7-d6) acetate  98% D
Synonyms:α-Tocopherol-d6 acetate;

母育酚              
dl-Tocol        250mg    /  4562元
97+ %
用途:生体内等のビタミンEの定量に使用される内標準物質「トコール」です    30306921

其它维生素 系列产品 Vitamin

水溶性维生素    
烟酸 Nicotinic acid C 15521000/250mg
盐酸吡哆醛(B6) Pyridoxal hydrochloride /
二盐酸吡哆胺(B6) Pyridoxamine dihydrchloride /
抗坏血酸钠 Sodium ascorbate C 10303900/250mg
盐酸硫胺(B1) Vitamin B1 hydrochloride C 17455000/250mg
硝酸硫胺(B1) Vitamin B1 mononitrate C 17455500/250mg
核黄素(B2) Vitamin B2 C 16813600/250mg
烟酰胺(B3/B5) Nicotinamide C 15519500/250mg
泛酸钙(B3/B5) Calcium pantothenate CA15845000/250mg
泛酸钠 D-Pantothenic acid sodium salt C 15845100/250mg
吡哆素(B6) Vitamin B6 /
盐酸吡哆素(B6) Vitamin B6 hydrochloride C 16652000/250mg
氰钴胺素(B12) Vitamin B12 CA11798500/50mg
对氨苯甲酸Bx Vitamin Bx C 10171400/100mg
抗坏血酸(C) Vitamin C C 10303000/250mg
抗坏血酸钙(C) Calcium ascorbate C 10303100/250mg
异抗坏血酸 D(-)-Isoascorbic acid C 14379000/250mg
生物素(H) Vitamin H C 10625000/250mg
叶酸 Folic acid C 13888000/250mg
     
脂溶性维生素    
视黄醇 Retinol R7632-100mg
维生素A酸 Tretinoin C 17608000/250mg
维生素A乙酸酯 Retinol acetate CA17923820/150mg
维生素A棕榈酸酯 Retinol palmitate CA17923840/150mg
胆钙化甾醇(D3) Cholecalciferol CA17924000/150mg
DL-a-生育酚(E) DL-a-Tocopherol CA17924300/500mg
DL-a-生育酚乙酯 DL-a-Tocopherylacetate CA17924320/500mg
维生素K1 Phytonadione C 17924400/250mg
甲萘醌(K3) Menadione C 14863000/250mg
b-胡萝卜素 b-Carotene CA11045800/250mg
虾青素 Astaxanthin 1mg,5mg
角黄素 Canthaxanthin CA10947000/150mg
硫辛酸 DL-6,8-Thioctic acid /
麦角钙化甾醇(D2) Ergocalciferol CA17923900/150mg
a-琥珀酸(E) a-Tocopheryl acid succinate 1mg
叶黄素 Lutein 1mg,5mg
Vitamin B    
39488 Cobamamide   25 mg/100 mg 
 Synonyms:Dibencozide; Coenzyme B12; 
Vitamin B12  
78400 Cyanocobalamin Impurity A  
78401 Cyanocobalamin Impurity B  
78399 Cyanocobalamin Impurity C   
D78402 Cyanocobalamin Impurity D  
78403 Cyanocobalamin Impurity E  
78396 Cyanocobalamin Impurity F 
78397 Cyanocobalamin Impurity G 
78398 Cyanocobalamin Impurity H 8-epi-Cyanocobalamin 
D19176 N-Acetyl Folic Acid-d4   1 mg/10 mg
 Synonyms:N-[4-[[[2-(Acetylamino)-1,4-dihydro-4-oxo-6-pteridinyl]methyl] amino]benzoyl-2,3,5,6-d4]-L-glutamic Acid;   
D32129 Folic Acid-d4   0.5 mg 
 Synonyms:Vitamin B9-d4;   
47108 Levomefolic acid  50 mg 
11491 Mecobalamin   10 mg/50 mg
 Synonyms:Methyl-5,6-dimethylbenzimidazolylcobalamin; Methyl Vitamin B12; MeCbl; Algobaz; Hitocobamin-M; Methycobal; Methylcobaz;   
18697 Methylcobalamin  5 mg/25 mg
    
5762 Niacin   1 g/5 g
 Synonyms:Nicotinic acid; 3-Picolinic acid; Pyridine-3-carboxylic acid; Vitamin B3;   
5761 Niacinamide   1 g 
 Synonyms:Nicotinamide; nicotinic acid amide;   
D2491 Nicotinic-d4 acid  98%D 25 mg 
 Synonyms:Nicotinic acid-ring-d4; 3-Pyridine-d4-carboxylic acid; Niacin-d4 (ring-d4); Vitamin B3-d4;   
D16289 Panthenol-d6 in ethanol  5 mg 
48464 Pyridoxal hydrochloride  1 g
D18013 Pyridoxal-d3  98% D 1 mg 
 Synonyms:3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde-d3; 4-formyl-5-hydroxymethylpyridine-d3; Vitamin B6-d3;   
D30561 Pyridoxal-d3 5’-phosphate  98.8%D 1 mg/5 mg 
 Synonyms:3-Hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4- pyridinecarboxaldehyde-d3; Pyridoxal-d3 Phosphate; Pyridoxal-d3 5-(Dihydrogen Phosphate); 2-Methyl-3-hydroxy-4-formyl-5-pyridyl-methylphosphoric Acid-d3; 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde-d3;   
D48465 Pyridoxal-d3 hydrochloride  1 mg/5 mg 
13259 Pyridoxamine dihydrochloride  5 g 
 Synonyms:4-(Aminomethyl)-5-hydroxy-6-methyl-3-pyridinemethanol Dihydrochloride, 2-Methyl-3-hydroxy-4-aminomethyl-5- hydroxmethylpyridine Dihydrochloride;   
D18014 Pyridoxamine-d3 dihydrochloride 98% D3 1 mg 
D48473 4-Pyridoxic acid-d3  1 mg 
D98756 Pyridoxine-d2   1 mg/5 mg
 Synonyms:5-Hydroxy-6-methyl-3,4-pyridinedimethanol-d2; 2-Methyl-4,5- bis(hydroxymethyl)-3-hydroxypyridine-d2; 5-Hydroxy-6-methyl-3,4- pyridinedimethanol-d2; Pyridoxol-d2; Adermin-d2; Bezatin-d2; Pirivitol-d2; Pyridoxin-d2;;   
D13260 Pyridoxine-d5  98%D 1 mg/5 mg 
Synonyms:5-Hydroxy-6-methyl-3,4-pyridinedimethanol-d5; 2-Methyl-4,5-bis(hydroxymethyl)-3-hydroxypyridine-d5; Pyridoxol-d5; Adermin-d5; Bezatin-d5; Pirivitol-d5; Pyridoxin-d5; Vitamin B6-d5;   
D18015 Pyridoxine-d3 hydrochloride  98% D 1 mg 
 Synonyms:5-Hydroxy-6-(methyl-d3)-3,4-pyridinedimethanol HCl; Pyridoxol-d3 HCl; Aderomine-d3 HCl; Aderoxin-d3; Hexobion-d3; Pyridox-d3; Vitamin B6-d3;   
D32202 Pyridoxine-d2 hydrochloride  98%D 10 mg 
 Synonyms:Vitamin B6-d2; Pyridoxol-d2 HCl;   
74338 Pyridoxine-5-phosphate HCl  10 mg 
D74337 Pyridoxine-d4 HCl  10 mg
D75074 Riboflavin-d6   
C33135 Vitamin B1-13C4 hydrochloride  99% 13C 5 mg 
 Synonyms:Aneurine hydrochloride; Thiamine-[13C4].HCl; Vitamin B1 hydrochloride;   
CN18019 Vitamin B2-13C4,15N2   1 mg 
 Synonyms:Vitamin B2-13C4,15N2; Riboflavin-13C4.15N2;   
D5862 Vitamin B1-d3 hydrochloride  95% D 1 mg 
 Synonyms:Thiamine-d3; Eskaphen-d3; Vitaneuron-d3; Begiolan-d3; Beatine-d3 ;   
D5864 Vitamin B5-d4 calcium salt  99%D 1 mg 
 Synonyms:deuterated Pantothenic Acid, Pantothenic Acid-d4;   
18575 Vitamin B12   100 mg 
 Synonyms:Cobalamin; Cyanocobalamin; Methylcobalamin; α-(5,6-Dimethylbenzimidazolyl)cyanocobamide, CN-Cbl, Cyanocob(III)alamin, Cyanocobalamin, Vitamin B12;   
33134 Vitamin B2   1 g 
 Synonyms:Riboflavin;   
D5863 Vitamin B3-d4  98%D 1 mg 
 Synonyms:Niacin, deuterated Niacin, Niacin-d4;   
33136 Vitamin B5   5 mg 
 Synonyms:Calcium Pantothenate;   
CN18030 Vitamin B5- 13C6,15N2  99% 13C6, 98% 15N2 1 mg 
 Synonyms:Calcium Pantothenate-13C6,15N2;   
33133 Vitamin B6   1 mg 
 Synonyms:Pyridoxine.HCl; Adermine hydrochloride, Becilan, Benadon, Campoviton 6, Hexabetalin, Hexabione hydrochloride, Hexavibex, Hexermin, Hexobion, 3-Hydroxy-4,5-dimethylol-α-picoline hydrochloride

Vitamin C
16203 L-Ascorbic Acid  25 g 100 g
Synonyms:Vitamin C; 
6929 Ascorbic Acid Acetonide  20 g 100 g 
Synonyms:5,6-O-Isopropylidene-L-ascorbic Acid;  
C32956 L-Ascorbic acid-1-13C  99% 13C 50 mg 
Synonyms:Vitamin C, 1-13C;  
C32957 L-ascorbic acid-2-13C  0.05 g/0.1 g
Synonyms:Vitamin C, 2-13C;  
C32958 L-ascorbic acid-3-13C  0.05 g/0.1 g
Synonyms:Vitamin C, 3-13C;  
C32959 L-ascorbic acid-5-13C  0.05 g/0.1 g 
Synonyms:Vitamin C, 5-13C;  
C32960 L-Ascorbic acid-6-13C   
Synonyms:Vitamin C, 6-13C;  
C32962 L-ascorbic acid-1,6-13C2  0.05 g/0.1 g
Synonyms:Vitamin C, 1,6-13C2;  
C32963 L-ascorbic acid-1,3-13C2  0.05 g/0.1 g 
Synonyms:Vitamin C, 1,3-13C2;  
C32965 L-Ascorbic acid-1,2-13C2  99%C 0.05 g/0.1 g
Synonyms:Vitamin C, 1,2-13C2;  
D32961 L-ascorbic acid-6,6-d2  0.25 g/0.5 g
Synonyms:Vitamin C, 6,6-d2;  
C32964 L-Ascorbic acid-U-13C6  50 mg/100 mg 
Synonyms:Vitamin C, U-13C6;  
D2234 Citric-2,2,4,4-d4 acid  98%D 10 mg/250 mg
Synonyms:2-Hydroxy-1,2,3-propanetricarboxylic-2,2,4,4-d4 Acid; 
2360 2-Methyl citric acid 100 mg 
76504 2-Phospho-L-ascorbic acid trisodium salt 10 mg  
D14581 Sodium Citrate-2,2,4,4-d4 98% D 50 mg 
 

上海惠诚生物科技有限公司 “惠质产品,挚诚服务”,主营糖化学标准品脂类分析标准品花青素标准品类胡萝卜素人乳寡糖等食品分析用产品,咨询电话021-60498804。